Autopsies Confirm That PI-2620 Binds 4R Tau Deposits
For the first time, scientists correlated the PET signal in PSP patients with tau deposits in postmortem brain; the signal arises from neurons and oligodendrocytes.
For the first time, scientists correlated the PET signal in PSP patients with tau deposits in postmortem brain; the signal arises from neurons and oligodendrocytes.
People born in the 1970s had 15 percent more surface area in their cortices than those born in the 1930s.
Equipped with ApoE3-Christchurch, microglia made short work of tau fibrils, and spewed fewer inflammatory cytokines.
Lecanemab will soon have maintenance dosing and subcutaneous formulations available; FDA advisory committee will consider donanemab June 10.
An adeno-associated virus that binds the transferrin receptor delivered β-glucocerebrosidase throughout the mouse brain.
APOE4 carriers who also have a glycine-to-glutamic-acid substitution in the extracellular matrix protein were much less likely to develop Alzheimer’s disease.
Blood and other in vitro assays will need to meet the same standards as medical devices, including demonstrating diagnostic accuracy.
By age 65, nearly all people who carry two copies of APOE4 harbor neuropathological or biomarker evidence of AD pathology.
Scientists have co-opted the transferrin receptor to ferry enzymes, antibodies, and other potential therapeutics into the brain. Now, they have done the same for viruses. Targeting an adeno-associated virus to the transferrin receptor boosted viral delivery into the mouse brain by 30-fold. The virus expressed β-glucocerebrosidase throughout the brain. This modified virus might improve the efficiency of gene therapy.
APOE4 is the strongest genetic risk factor for sporadic AD. Yet some carriers evade the disease entirely. How? By having rare protective variants in other genes, say scientists. Among 510 such rare coding mutations, one in the gene for fibronectin reduced AD risk in APOE4 homozygotes by 71 percent. Those who did develop AD got symptoms 3.5 years later than non-variant carriers. Cognitively healthy APOE4 carriers had less gliosis and fibronectin surrounding blood vessels in the brain than did those with AD.
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